CBD Oil for Dogs: What You Need to Know
Recently, more and more research has shown us that CBD oil is both safe and beneficial for dogs. Here’s what you need to know.
Anxiety, insomnia, pain, seizures – CBD products can potentially help with many health conditions, making it a versatile and highly beneficial supplement. What makes it even more versatile is that CBD oil can help animals as well as humans. Recently, more and more researchers have looked into using CBD oil for dogs.
CBD works for dogs because, as with all mammals, every dog has an endocannabinoid system. This system affects all parts of your dog’s body – their skin, mood, brain, and beyond. As with humans, the endocannabinoid system is affected by cannabinoids, which are the active ingredients in cannabis and hemp. CBD is one cannabinoid that can affect your dog’s endocannabinoid system for the better.
Why is CBD good for dogs?
CBD can treat a number of canine ailments. Studies have shown that CBD can treat a number of ailments in both humans and dogs.
Recent research has shown that CBD can help dogs in the following ways:
A study conducted in 2012 indicated that CBD, which is a natural anti-inflammatory, improved the skin of dogs with inflammatory skin conditions.
A 2017 study looked at the effects of CBD oil on epileptic dogs. The study found that the dogs who had CBD oil had fewer seizures than those who had a placebo. It found that CBD was an effective way to treat seizure-prone dogs.
A 2018 study on dogs with osteoarthritis found that CBD oil reduced pain and helped them be more active than usual.
In addition to the above studies, a recent survey of US veterinarians showed that many vets felt that CBD was an effective treatment for managing pain, relieving anxiety, and decreasing the frequency and severity of seizures.
Of course, CBD oil might be able to treat even more conditions than those mentioned above. We know that CBD has been shown to reduce inflammation, depression, and pain, among other things. Further research is needed to verify the other benefits that CBD might offer dogs.
What you need to know about buying CBD oil for your dog
It’s important to be sure that you’re buying quality CBD oil. The packaging should state that the oil contains CBD. It should also state how much CBD the oil the product contains in milligrams (mg). Remember that products labeled ‘hemp oil’ don’t always contain CBD, as not all parts of the hemp plant contains CBD.
So far, research has indicated that CBD oil is safe for dogs. It’s unlikely that your pet will experience any side-effects, although it might make them a little sleepy.
If the oil is THC-free, it should not get your dog high. THC is the intoxicating element of cannabis, but CBD isn’t intoxicating. Bottom line? CBD is widely considered safe for your dog to consume.
It’s always a good idea to speak with your veterinarian about using CBD oil for your pet. A recent paper found that only 45.5% of US veterinarians felt comfortable discussing CBD oil with clients and many didn’t feel confident in their knowledge of CBD oil, although most believe that CBD can be beneficial for pets. So, be sure to seek out a veterinarian that has experience with using CBD.
Some cannabis CBD oil also contains THC, the cannabinoid in cannabis that makes you high. THC can intoxicate dogs, and we know that cannabis is toxic to dogs.
There aren’t any specific laws to outlaw giving your dogs cannabis oil, but it might harm them, so it’s best to give them hemp CBD oil and avoid THC containing products for your dog.
The difference between humans and dogs when it comes to CBD
The primary difference between treating humans with CBD and treating dogs with CBD is that there is more research focusing on humans than on dogs.
Because dogs can’t speak for themselves, it’s important that you monitor your pup’s behavior after you give them CBD. If you give them the correct dosage it’s unlikely that they’ll experience any side effects, but it’s important to be cautious whenever giving your pet a new supplement. If you’re concerned about using CBD for your dog, speak with a holistic veterinarian.
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1 full dropper (1 ml), once a day
16 mg of CBD per serving (DOGS OVER 50LBS)
Our highly medicated CBD Pet Drops is CBD oil that is safe for your pets.
Each 1oz container contains 500 mg of CBD oil that is sublingual (drops under your pets tongue) or added to their food. This product is all-natural and safe for pets. No artificial flavoring or coloring. From CO2 extracted oil that is derived from the flowers of the industrial hemp plant. 100% CBD No THC. Hemp is rich in CBD, also known as Cannabidiol. There are no known side effects.
Pets under 25 pounds: Start with 0.25 ml
Pets over 25 and under 50 pounds: Start with 0.5 ml
Pets over 50 pounds 1 ml
All pets might react different. Please monitor your pets to ensure they are receiving proper dosage. CBD has no serious side effects and you can start or stop taking it at any time. Use daily for maximum effectiveness.
CBD oil that you purchase for your dogs must be hemp extract derived from CO2 extraction of the hemp plant. CBD derived from the other species of the cannabis sativa plant (marijuana) will contain trace amounts of THC. THC isn't safe for canines even in small amounts. It is imperative that the CBD oil that you purchase is all natural, all the time. This means that the hemp product was not treated with any pesticides, fungicides, or solvents.
CO2 extraction is already a conventional extraction method in the food and herbal supplement industries. CO2 extraction guarantees that your concentrates will not only be cleaner, but significantly healthier for consumption.
CO2 extraction, eliminates the need for use ethanol alcohol to winterize and use butane to extract or de-wax the cannabis oils~Due to the lack of chemicals and preservation of terpene aromas, CO2 extracted oil is also much better tasting, making them ideal for cannabis concentrates.
The main thing consumers should take away is that the method of extraction using CO2 produces cannabis concentrates that are overall more appealing and much safer. Specifically, the method of extraction using supercritical CO2 produces cannabis concentrates that are cleaner and have significantly less toxicity.
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CBD (cannabidiol) is a non-intoxicating component of the hemp plant with enormous therapeutic potential. Although CBD doesn’t make people or pets feel high like THC does, it’s causing quite a buzz among scientists, health professionals, and medical marijuana patients who are using CBD-rich products to treat a wide range of conditions—chronic pain, cancer, Crohn’s, diabetes, rheumatoid arthritis, PTSD, cardiovascular disease, anxiety, antibiotic-resistant infections, multiple sclerosis, and more.
Academic research centers in the United States and elsewhere are currently studying the effects of CBD on these and other ailments. Scientists refer to CBD as a “promiscuous” compound because it confers therapeutic benefits in many different ways while tapping into how we function physiologically and biologically on a deep level. Extensive preclinical research and some clinical studies have shown that CBD has strong anti-oxidant, anti-inflammatory, anticonvulsant, anti-depressant, anti-tumoral, and neuroprotective qualities. Cannabidiol can change gene expression and remove beta amyloid plaque, the hallmark of Alzheimer’s, from brain cells.
What Are the Benefits of CBD for your high performance dog?
CBD can be used to treat seizures, nausea, stress, anxiety, arthritis, and gastrointestinal issues, among other health conditions in dogs. Relief is provided through the endocannabinoid system, Dr. Shu explains. “It’s a series of receptors that run throughout the body,” he says. “The cannabinoids interact with the receptors in the body and modulate things like pain, anxiety, and nausea.”
Unlike some traditional pain medicine for dogs, CBD has no life-threatening side effects with proper dosage, It doesn’t damage the kidney, liver, or GI tract. The dogs aren’t high or sedated. [Aly Semigran~ https://www.petmd.com/dog/general-health/cannabis-oil-dogs-everything-you-need-know ]
CBD is non-psychoactive, which means that it doesn’t produce the “high” commonly associated with marijuana. CBD is currently used by many patients (human and animal) who seek an alternative form of therapy without the unwanted side effects. CBD has been shown to have potent anti-arthritic therapeutic action, resulting in both joint protection and clinical sign improvement.1 “Oral CBD has a beneficial action on two symptoms of established inflammation: [swelling and sensitivity to pain]” 2 Furthermore, studies indicate chronic use of CBD has not been shown to elicit negative side effects and does not induce tolerance.
1Malfait, A., Gallily, R., Sumariwalla, P., Malik, A., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences, 9561-9566.
2Costa, B., Colleoni, M., Conti, S., Parolaro, D., Franke, C., Trovato, A., & Giagnoni, G. (2004). Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naunyn-Schmiedeberg’s Archives of Pharmacology, 294-299.
CBD Education ~ CBD Science
Cannabidiol (CBD), a non-intoxicating component of the cannabis plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol is a pleiotropic drug in that it produces many effects through multiple molecular pathways. The scientific literature has identified more than 65 molecular targets of CBD.
Although CBD has little binding affinity for either of the two cannabinoid receptors (CB1 and CB2), cannabidiol modulates several non-cannabinoid receptors and ion channels. CBDalso acts through various receptor-independent pathways—for example, by delaying the “reuptake” of endogenous neurotransmitters (such as anandamide and adenosine) and by enhancing or inhibiting the binding action of certain G-protein coupled receptors.
Here are some of the ways that CBD confers its manifold therapeutic effects.
Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London have conducted pioneering research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect. This G-coupled protein receptor is implicated in a range of biological and neurological processes, including (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea and vomiting.
5-HT1A is a member of the family of 5-HT receptors, which are activated by the neurotransmitter serotonin. Found in both the central and peripheral nervous systems, 5-HT receptors trigger various intracellular cascades of chemical messages to produce either an excitatory or inhibitory response, depending on the chemical context of the message.
CBDA [Cannabidiolic acid], the raw, unheated version of CBD that is present in the cannabis plant, also has a strong affinity for the 5-HT1A receptor (even more so than CBD). Preclinical studies indicate that CBDA is a potent anti-emetic, stronger than either CBD or THC, which also have anti-nausea properties.
CBD directly interacts with various ion channels to confer a therapeutic effect. CBD, for example, binds to TRPV1 receptors, which also function as ion channels. TRPV1 is known to mediate pain perception, inflammation and body temperature.
TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.” TRPV1 is one of several dozen TRP (pronounced “trip”) receptor variants or subfamilies that mediate the effects of a wide range of medicinal herbs.
Scientists also refer to TRPV1 as a “vanilloid receptor,” named after the flavorful vanilla bean. Vanilla contains eugenol, an essential oil that has antiseptic and analgesic properties; it also helps to unclog blood vessels. Historically, the vanilla bean has been used as a folk cure for headaches.
CBD binds to TRPV1, which can influence pain perception.
Capsaicin—the pungent compound in hot chili peppers—activates the TRVP1 receptor. Anandamide, the endogenous cannabinoid, is also a TRPV1 agonist.
Whereas cannabidiol directly activates the 5-HT1A serotonin receptor and several TRPV ion channels, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55.
GPR55 has been dubbed an “orphan receptor” because scientists are still not sure if it belongs to a larger family of receptors. GPR55 is widely expressed in the brain, especially in the cerebellum. It is involved in modulating blood pressure and bone density, among other physiological processes.
GPR55 promotes osteoclast cell function, which facilitates bone reabsorption. Overactive GPR55 receptor signaling is associated with osteoporosis.
GPR55, when activated, also promotes cancer cell proliferation, according to a 2010 study by researchers at the Chinese Academy of Sciences in Shanghai. This receptor is expressed in various types of cancer.
CBD is a GPR55 antagonist, as University of Aberdeen scientist Ruth Ross disclosed at the 2010 conference of the International Cannabinoid Research Society in Lund, Sweden. By blocking GPR55 signaling, CBD may act to decrease both bone reabsorption and cancer cell proliferation.
PPARs – nuclear receptors
CBD also exerts an anti-cancer effect by activating PPARs [peroxisome proliferator activated receptors] that are situated on the surface of the cell’s nucleus. Activation of the receptor known as PPAR-gamma has an anti-proliferative effect as well as an ability to induce tumor regression in human lung cancer cell lines. PPAR-gamma activation degrades amyloid-beta plaque, a key molecule linked to the development of Alzheimer’s disease. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful remedy for Alzheimer’s patients.
PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. Diabetics, accordingly, may benefit from a CBD-rich treatment regimen.
CBD as a reuptake inhibitor
How does CBD, an exogenous plant compound, get inside a human cell to bind to a nuclear receptor? First it has to pass through the cell membrane by hitching a ride with a fatty acid binding protein (FABP), which chaperones various lipid molecules into the cell’s interior. These intracellular transport molecules also escort tetrahydrocannabinol (THC) and the brain’s own marijuana-like molecules, the endocannabinoids anandamide and 2AG, across the membrane to several targets within the cell. CBD and THC both modulate receptors on the surface of the nucleus, which regulate gene expression and mitochondrial activity.
Cannabidiol, it turns out, has a strong affinity for three kinds of FABPs, and CBD competes with our endocannabinoids, which are fatty acids, for the same transport molecules. Once it is inside the cell, anandamide is broken down by FAAH [fatty acid amide hydrolase], a metabolic enzyme, as part of its natural molecular life cycle. But CBD interferes with this process by reducing anandamide’s access to FABP transport molecules and delaying endocannabinoid passage into the cell’s interior.
According to a team of Stony Brook University scientists, CBD functions as an anandamide reuptake and breakdown inhibitor, thereby raising endocannabinoid levels in the brain’s synapses. Enhancing endocannabinod tone via reuptake inhibition may be a key mechanism whereby CBD confers neuroprotective effects against seizures, as well as many other health benefits.
CBD’s anti-inflammatory and anti-anxiety effects are in part attributable to its inhibition of adenosine reuptake. By delaying the reuptake of this neurotransmitter, CBD boosts adenosine levels in the brain, which regulates adenosine receptor activity. A1A and A2A adenosine receptors play significant roles in cardiovascular function, regulating myocardial oxygen consumption and coronary blood flow. These receptors have broad anti-inflammatory effects throughout the body.
CBD as the allosteric receptor modulator
CBD also functions as an allosteric receptor modulator, which means that it can either enhance or inhibit how a receptor transmits a signal by changing the shape of the receptor.
Australian scientists report that CBD acts as a “positive allosteric modulator” of the GABA-A receptor. In other words, CBD interacts with the GABA-A receptor in a way that enhances the receptor’s binding affinity for its principal endogenous agonist, gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. The sedating effects of Valium and other Benzos are mediated by GABA receptor transmission. CBD reduces anxiety by changing the shape of the GABA-A receptor in a way that amplifies the natural calming effect of GABA.
Canadian scientists have identified CBD as a “negative allosteric modulator” of the cannabinoid CB1 receptor, which is concentrated in the brain and central nervous system. While cannabidiol doesn’t bind to the CB1 receptor directly like THC does, CBDinteracts allosterically with CB1 and changes the shape of the receptor in a way that weakens CB1’s ability to bind with THC.
As a negative allosteric modulator of the CB1receptor, CBD lowers the ceiling on THC’s psychoactivity—which is why people don’t feel as “high” when using CBD-rich cannabis compared to when they consume THC-dominant medicine. A CBD-rich product with little THC can convey therapeutic benefits without having a euphoric or dysphoric effect.
Cannabis has been at the center of one of the most exciting—and underreported—developments in modern science. Research on marijuana’s effects led directly to the discovery of a hitherto unknown biochemical communication system in the human body, the Endocannabinoid System, which plays a crucial role in regulating our physiology, mood, and everyday experience.
The discovery of receptors in the brain that respond pharmacologically to cannabis—and the subsequent identification of endogenous cannabinoid compounds in our own bodies that bind to these receptors—has significantly advanced our understanding of human biology, health, and disease.
Every day, more and more people are experiencing the remarkable benefits of CBD (Cannabidiol). From relieving joint pain and arthritis to managing anxiety and preventing inflammation, CBD oil is changing the ways in which individuals can manage and treat their pet's health conditions. CBD oil proves to be not only safe, but incredibly effective for dogs~experts have been researching its effects on animals for well over three decades
CBD proves to:
Manage and prevent anxiety
Lessen the frequency and severity of seizures
CBD for pain (in fact, CBD is so effective that experts are considering it to be a new drug class for the treatment of chronic pain in animals and people alike)
Reduce and prevent inflammation (and therefore prevent diseases stemming from inflammation)
Reduce and prevent nausea
Boost the appetite
Have an anti-tumor effects
Shrink cancer cells
Promote overall wellness
Boost the immune system
As you can see, CBD oil not only reduces and manages present health concerns but also serves as a powerful preventative measure